Potaro-Siparuni (Region 8) is a region of Guyana. It borders the region of Cuyuni-Mazaruni to the north, the regions of Upper Demerara-Berbice and East Berbice-Corentyne to the east, the region of Upper Takutu-Upper Essequibo to the south and Brazil to the west.
The main villages in the region are Campbelltown, Orinduik, Mahdia, Paramakatoi and Tumatumari.