Upper Takutu-Upper Esequibo (Region 9) is a region of Guyana. It borders the region of Potaro-Siparuni to the north, the region of East Berbice-Corentyne to the east and Brazil to the south and west. It contains the town of Lethem, and the villages of Aishalton, Nappi and Surama. It is also the largest region of Guyana.
The Rupununi savannah known for its large biodiversity is located between the Rupununi River and the Brazilian border. Within the Upper Takutu-Upper Esequibo is part of the Guianan savanna ecoregion.